Adderall and QTc Prolongation
The Food and Drug Administration (FDA) held a meeting to discuss the risks associated with methylphenidate hydrochloride, a stimulant used to treat ADHD. The study cited Shahar E, Whitney C, Redline S, and Leung R. Their studies focused on sleep-disordered breathing and autonomic mechanisms. The results were inconclusive when it comes to the cardiovascular risk associated with Adderall and other stimulants.
The effects of this CNS stimulant drug on cardiovascular function are not fully understood. However, some evidence suggests that these drugs can prolong the QT interval in some patients. They have a risk of arrhythmia and torsades de pointes, which can cause serious complications. They should be taken in low-doses and for short durations. This medication is not recommended for children with severe heart problems.
The MAS-XR is a delayed-release form of Adderall. The drug is released gradually over 4 hours. The delayed-release form of Adderall contains the same dosage ratio as the immediate-release tablets. The MAS-XR dose can be adjusted up to 40 mg daily for optimal efficacy. The study also showed no difference in blood pressure, pulse rate, or QTc intervals.
The MAS-XR is a formulation of dexamfetamine and levoamfetamine in a 3:1 ratio. It is a delayed-release form of Adderall, and begins to release the active drug about four hours after ingestion. The dosage is also adjustable up to forty mg per day for optimal effect. The MAS-XR did not alter heart rate, blood pressure, or the QT interval, which is a side effect of stimulant therapy.
In a clinical study, armodafinil was administered to 2968 patients with ADHD. During the study, the drug was administered to patients in the same way as the immediate-release tablets. Its effects were similar to those of the MAS-IR, but it had a slightly longer QT. The drug had no adverse effects on blood pressure, heart rate, or the QT interval.
The drug’s effects aren’t immediately clear. Its effects on the heart have been controversial, and some have found it to be ineffective. But the drug remains a popular and effective medication in many cases. Despite the potential risks, it’s important to note the safety of stimulants. These medications may increase the risk of cardiac events. They should not be taken without medical supervision. If you’re taking Adderall, you should follow the FDA’s instructions carefully.
Bobby Pruett joined BestNootropics.org in 2021. As a freelance journalist, Tim has written stories for publications such as BuzzFeed and the Huffington Post. He moved to Boston in 2019, and currently covers the health stories at BestNootropics.org.